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. 2021 Jul 29;12:703931. doi: 10.3389/fimmu.2021.703931

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Copyright © 2021 Liu, Zhang, Zhang, Yuan, Du, Zeng, Huang, Jia, Yang, Shi and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tocilizumab alters the expression level of activation marker. (A–D) was the representative flow cytometric histogram after surface staining activation marker on total B cells (CD19⁺) from NMOSD patients before and after tocilizumab treatment. (E–H) was the quantitative analysis of the mean fluorescence intensity (MFI) of CD86, CD69, BAFF-R, HLA-DR in CD19⁺cells before and after tocilizumab treatment. Difference was considered statistically significant for P < 0.05. Paired, two-tailed Student’s t tests were used, n=26.