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. 2021 Jul 29;12:703931. doi: 10.3389/fimmu.2021.703931

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Copyright © 2021 Liu, Zhang, Zhang, Yuan, Du, Zeng, Huang, Jia, Yang, Shi and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of PD-1 and its corresponding ligands PD-L1 and PD-L2 on B cells subsets from healthy control (HC) and NMOSD patients before and after treatment. (A, C, E) Representative histograms of PD-1, PD-L1, PD-L2 in several B cells subsets from a healthy control and NMOSD patients before and after treatment. (B, D, F) was the quantitative analysis of mean fluorescence intensity (MFI) of PD-1, PD-L1&PD-L2 in several B cells subsets. Unpaired, two-tailed Student’s t tests (if the distribution is normal) or Mann-Whitney U tests (if it does not conform to the normal distribution) were used, n=26.