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. 2021 Jul 15;41(8):642–660. doi: 10.1002/cac2.12188

TABLE 3.

Retrospective database analysis for PNI in PDAC

Year No. of patients Analysis model(s) Association with PNI Prognosis significance P value/OR Reference(s)
1996 113 (69.9%)

Kaplan‐Meier analysis;

Cox proportional hazards analysis

 Negative Not an independent risk factor 0.01 [98]
2002 24 (70.8%)

Kaplan‐Meier analysis;

Cox proportional hazards analysis

 Negative NA NA [99]
2006 56 (NA)

Kaplan‐Meier analysis;

Cox proportional hazards analysis

 Negative Prognostic parameters < 0.01 [19]
2007 33 (57.6%) Kaplan‐Meier analysis Negative NA 0.023 [100]
2007 75 (65.3%)

Kaplan‐Meier analysis;

Cox proportional hazards analysis

 Negative Prognostic parameters 0.034 [10]
2010 96 (53.1%) Log‐rank test; Cox multi‐regression analysis Negative Prognostic parameters 0.0001 [101]
2011 95 (88.0%) Kaplan‐Meier analysis; univariate and multivariate Cox regression analysis Negative NA 0.02 [140]
2012 212 (58%)

Kaplan‐Meier analysis;

Cox regression analysis;

Cox proportional hazards models

 Negative NA 0.03 [108]
2015 209 (94%)

Kaplan‐Meier analysis;

Cox proportional hazards analysis

 Negative Prognostic parameters 0.0001 [104]
2016 173 (60.7%) Multivariate Logistic Regression Negative Absence of PNI is independently associated with increased odds of long‐term survival 0.036 [106]
2016 59 (50.8%) Kaplan‐Meier analysis; multivariate Cox regression analysis Negative Prognostic parameters 0.0009 [109]
2017 3538 (76.2‐97.8%) Meta‐analysis Negative Prognostic parameters < 0.00001 [141]
2019 17,313 (NA) Meta‐analysis Negative Risk factors for recurrence OR: 5·19, 2·79 to 9·64 [110]
2020 778 (87%) Kaplan‐Meier analysis; multivariable Cox proportional hazards models Negative Prognostic parameters 0.01 [102]
2020 400 (87.7%) Kaplan‐Meier analysis; univariate and multivariate Cox regression analysis Negative Prognostic parameters 0.05 [103]