Table 1.
Values for integral of synaptic currents, amplitude and duration Ca2+ signals during step depolarization of OHCs or MOC stimulation at 20-, 40-, and 80-Hz trains, in different pharmacological conditions
| Q (pC) | ΔF/F0 (%) | FWHM (s) | ||
|---|---|---|---|---|
| Depolarization | Ctrl (DMSO) | — | 3.3 ± 0.8 (n = 10) | 0.22 ± 0.04 (n = 7) |
| Ryanodine 100 μm | — | 6.4 ± 1.9 (n = 7) | 0.21 ± 0.08 (n = 7) | |
| Dantrolene 30 μm | — | 13.2 ± 4.7 (n = 7) | 0.27 ± 0.07 (n = 7) | |
| Ryanodine 1 μm | — | 15.8 ± 3.5 (n = 10) | 0.35 ± 0.02 (n = 10) | |
| 20 Hz | Ctrl (DMSO) | 20.0 ± 4.0 (n = 11) | 3.2 ± 0.4 (n = 11) | 0.17 ± 0.03 (n = 11) |
| Ryanodine 100 μm | 20.6 ± 3.5 (n = 8) | 5.0 ± 1.1 (n = 8) | 0.22 ± 0.04 (n = 8) | |
| Dantrolene 30 μm | 12.8 ± 2.0 (n = 6) | 3.9 ± 1.2 (n = 6) | 0.20 ± 0.04 (n = 6) | |
| Ryanodine 1 μm | 17.1 ± 4.9 (n = 10) | 4.5 ± 0.9 (n = 10) | 0.18 ± 0.04 (n = 10) | |
| 40 Hz | Ctrl (DMSO) | 34.3 ± 5.0 (n = 11) | 6.0 ± 1.8 (n = 11) | 0.28 ± 0.04 (n = 11) |
| Ryanodine 100 μm | 31.6 ± 4.4 (n = 8) | 7.0 ± 1.6 (n = 8) | 0.30 ± 0.02 (n = 8) | |
| Dantrolene 30 μm | 25.6 ± 3.3 (n = 6) | 6.0 ± 1.7 (n = 6) | 0.24 ± 0.05 (n = 6) | |
| Ryanodine 1 μm | 37.1 ± 6.3 (n = 10) | 10.9 ± 1.5 (n = 10) | 0.30 ± 0.04 (n = 10) | |
| 80 Hz | Ctrl (DMSO) | 61.2 ± 6.3 (n = 11) | 11.7 ± 1.6 (n = 11) | 0.43 ± 0.05 (n = 11) |
| Ryanodine 100 μm | 47.7 ± 5.7 (n = 8) | 11.9 ± 2.6 (n = 8) | 0.49 ± 0.04 (n = 8) | |
| Dantrolene 30 μm | 42.4 ± 2.1 (n = 6) | 10.3 ± 2.2 (n = 6) | 0.58 ± 0.07 (n = 6) | |
| Ryanodine 1 μm | 60.3 ± 6.7 (n = 10) | 16.9 ± 1.9 (n = 10) | 0.43 ± 0.04 (n = 10) |