Skip to main content
. 2021 Aug 11;41(32):6946–6953. doi: 10.1523/JNEUROSCI.0285-21.2021

Figure 5.

Figure 5.

JZL alters stimulus-specific changes in dopamine release. a, Mean (+SEM) DA concentration change (Δ[DA]) relative to stimulus onset (vertical line) across all mice and sessions following VEH or JZL treatment. Horizontal line represents the reference point (i.e., 0 nA) for quantifying Δ[DA]. b–d, Mean (±SEM) stimulus-evoked Δ[DA] across all sessions and treatments (two-way ANOVA; stimulus: F(2,2514) = 15.20, p < 0.001; drug: F(1,2514) = 7.98, p < 0.01; b) and separated into bins representing one-half of the total trials, relative to each stimulus (c, d). Separate two-way RM ANOVAs revealed a significant effect of time for Δ[DA] CueS (F(1,419) = 12.12, p < 0.001) and Δ[DA] CueT (F(1,419) = 66.14, p < 0.001), but not Δ[DA] Rew (F(1,419) = 0.90, p = 0.34). A significant treatment effect was observed only for Δ[DA] CueT (two-way RM ANOVA; drug: F(1,419) = 8.94, p < 0.01). Post hoc comparison of Δ[DA] relative to VEH, *p < 0.05, **p < 0.01.