Table 3.
Comparing the Varied Impacts of PDCwm and DPPR Measures Compared to PDCwith≥1
| Decision Node | Case | PDCwith≥1 Median (Q1–Q3) | PDCwm | DPPR | ||
|---|---|---|---|---|---|---|
| Median (Q1–Q3) | %Change from PDCwith≥1 | Median (Q1–Q3) | %Change from PDCwith≥1 | |||
| Base-case setting | 86.80 (63.05–96.15) | 83.59 (59.89–94.92) | −3.70 | 86.39 (62.58–95.84) | −0.47 | |
| Category 1: Definition of data cleaning | ||||||
| 1. Elimination claims that are irregular for hypertension medication | ||||||
| Smallest | a. In-hospital medication initiation | 85.96 (61.70–95.75) | 82.80 (58.66–94.58) | −3.68 | 85.66 (61.35–95.49) | −0.35 |
| Largest | c. Short-term prescribing under 7 days | 86.80 (63.05–96.15) | 83.59 (59.89–94.92) | −3.70 | 86.39 (62.58–95.84) | −0.47 |
| 2. Elimination of redundant duplicate claims | ||||||
| Smallest | a. Deduplication | 86.80 (63.05–96.15) | 83.59 (59.89–94.92) | −3.70 | 86.39 (62.58–95.84) | −0.47 |
| Largest | b. Leave as it was | 87.37 (63.48–96.47) | 84.03 (60.29–95.17) | −3.82 | 86.98 (62.99–96.13) | −0.45 |
| Category 2: Inclusion criteria and observation period | ||||||
| 3. Inclusion criteria for a minimum number of prescriptions | ||||||
| Smallest | a. At least two prescriptions | 86.80 (63.05–96.15) | 83.59 (59.89–94.92) | −3.70 | 86.39 (62.58–95.84) | −0.47 |
| Largest | b. At least four prescriptions | 86.81 (63.39–96.12) | 83.59 (60.23–94.85) | −3.71 | 86.40 (62.92–95.79) | −0.47 |
| 4. Inclusion criteria for pre-index period | ||||||
| Smallest | a. 180 days | 85.68 (61.50–95.87) | 82.27 (58.10–94.49) | −3.98 | 85.29 (61.01–95.52) | −0.46 |
| Largest | c. 730 days | 87.51 (64.13–96.34) | 84.38 (61.09–95.13) | −3.58 | 87.15 (63.79–96.00) | −0.41 |
| 5. Inclusion criteria for supply for the minimum cumulative number of days | ||||||
| Smallest | a. 30 days | 85.74 (59.14–96.05) | 82.36 (55.92–94.77) | −3.94 | 85.33 (58.64–95.71) | −0.48 |
| Largest | d. 1 year | 89.77 (73.60–96.72) | 86.73 (69.46–95.71) | −3.39 | 89.48 (73.17–96.44) | −0.32 |
| 6. Observation period | ||||||
| Smallest | e. 8 years | 83.37 (57.92–95.06) | 76.22 (52.19–91.86) | −8.58 | 82.97 (57.59–94.75) | −0.48 |
| Largest | a. 1 year | 91.41 (76.61–97.83) | 90.12 (74.28–97.07) | −1.41 | 90.93 (76.08–97.33) | −0.53 |
| Category 3: Calculation methods of medication adherence | ||||||
| 7. Handling end-date-of-study | ||||||
| Smallest | b. Fixed period-based approach | 82.76 (50.55–95.16) | 79.10 (48.08–93.80) | −4.42 | 82.44 (50.09–94.89) | −0.39 |
| Largest | a. Prescription-based approach | 86.80 (63.05–96.15) | 83.59 (59.89–94.92) | −3.70 | 86.39 (62.58–95.84) | −0.47 |
| 8. Handling overlaps | ||||||
| Smallest | a. No carryover was granted | 84.08 (61.50–92.75) | 81.06 (58.07–91.76) | −3.59 | 83.73 (61.00–92.56) | −0.42 |
| Largest | b. Carryover of overlaps unconditionally | 86.80 (63.05–96.15) | 83.59 (59.89–94.92) | −3.70 | 86.39 (62.58–95.84) | −0.47 |
Abbreviations: PDCwith≥1, proportion of days covered with one or more medications; PDCwm, duration weighted mean PDC; DPPR, daily polypharmacy possession ratio.