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. 2021 Feb 12;70(9):2577–2587. doi: 10.1007/s00262-020-02825-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Association of the PD-L1 amplification status with single immune cells counts within the adenocarcinoma (AC) and squamouscell carcinoma (SqCC) tumor subgroups of the Uppsala 06 cohort. Immune cells counts were determined by IHC. Box plots indicate the median with the interquartile range and the whiskers represent the 5–95 percentiles. Outliners are represented as dots. b Hierarchical cluster analysis using Ward’s method and Euclidian distance of the IHC based immune marker annotation and its association with PD-L1 amplification status and tumor histology