Table 3.

The association of selenium levels with all-cause mortality and cardiovascular mortality.

	Crude analysis HR (95%CI) P-value	Adjusted model HR (95%CI) P-value	Fully adjusted model HR (95%CI) P-value
All-cause mortality
Selenium per 10 μg/L increment	0.98 (0.92, 1.04) 0.4502	0.95 (0.90, 1.01) 0.0842	0.96 (0.90, 1.03) 0.2486
Selenium quartiles
Q1	1.0	1.0	1.0
Q2	0.88 (0.65, 1.18) 0.3826	0.75 (0.56, 1.01) 0.0555	0.74 (0.54, 1.03) 0.0715
Q3	0.60 (0.43, 0.83) 0.0024	0.56 (0.40, 0.78) 0.0006	0.57 (0.39, 0.81) 0.0020
Q4	0.83 (0.61, 1.12) 0.2238	0.72 (0.53, 0.97) 0.0333	0.74 (0.53, 1.04) 0.0802
p for trend	0.0574	0.0110	0.0419
Cardiovascular disease mortality
Selenium per 10 μg/L increment	1.05 (0.93, 1.18) 0.4572	1.01 (0.90, 1.14) 0.8215	1.03 (0.90, 1.17) 0.6882
Selenium quartiles
Q1	1.0	1.0	1.0
Q2	0.53 (0.25, 1.14) 0.1046	0.42 (0.20, 0.91) 0.0279	0.38 (0.16, 0.90) 0.0276
Q3	0.38 (0.16, 0.90) 0.0281	0.35 (0.15, 0.82) 0.0166	0.33 (0.13, 0.86) 0.0226
Q4	1.10 (0.58, 2.05) 0.7761	0.94 (0.50, 1.76) 0.8500	0.94 (0.46, 1.90) 0.8582
p for trend	0.9070	0.8987	0.9652

HR, hazard ratio; CI, confidence interval. Ref, reference. Crude analysis adjust for none; Adjusted model adjust for: age, sex, and race; Fully adjusted model adjust for: age, sex, race, education level, marital status, smoking, body mass index, systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, C-reactive protein, alcohol consumption, estimated glomerular filtration rate, comorbidities (cardiovascular disease, diabetes, and cancer), and medication use (lipid-lowering drugs, hypoglycemic agents, antiplatelet drugs, and antihypertensive drugs).

P-value by Cox proportional hazard regression models.