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. 2021 Jul 30;8:671618. doi: 10.3389/fcvm.2021.671618

Table 4.

The results of two-piecewise linear regression model between selenium levels and all-cause or cardiovascular mortality.

All-cause mortality
HR (95% CI) P-value
Cardiovascular mortality
HR (95% CI) P-value
Cutoff value, μg/L 136 130
<Cut-off value (per 10 μg/L increment) 0.75 (0.66, 0.85) <0.0001 0.60 (0.42, 0.86) 0.0051
>Cut-off value (per 10 μg/L increment) 1.08 (1.01, 1.16) 0.0207 1.15 (1.02, 1.31) 0.0255
P for log likelihood ratio test <0.001 0.004

HR, hazard ratio; CI, confidence interval.

Two-piecewise linear regression model were adjusted for age, sex, race, education level, marital status, smoking, body mass index, systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, C-reactive protein, alcohol consumption, estimated glomerular filtration rate, comorbidities (cardiovascular disease, diabetes, and cancer), and medication use (lipid-lowering drugs, hypoglycemic agents, antiplatelet drugs, and antihypertensive drugs).

P-value by two-piecewise Cox proportional hazards model.