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. 2021 Feb 12;70(9):2617–2624. doi: 10.1007/s00262-021-02876-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Baseline images and response evaluation after treatment with pembrolizumab in study patient 12 (PROMO-12). a CT images and b 18F-FDG PET/CT images at baseline (left panel) and after two cycles of pembrolizumab (right panel). Arrows indicate reduced uptake of 18F-FDG and tumor size in lung and kidney metastases, and arrowheads indicate progressive abdominal and pelvic metastases