Table 2.
Stromal tumor-infiltrating lymphocytes (TILs) in colorectal cancer and its association with clinicopathological data and immune regulatory molecules
| Variables | Immune cells | |||
|---|---|---|---|---|
| CD3+ | CD4+ | CD8+ | CD45+ | |
| r (Pearson test) | ||||
| p value (2-tailed) | ||||
| TNM stage | r = −0.2867 | r = −0.3708 | r = −0.1337 | r = −0.1142 |
| p = 0.0822 | p = 0.0008 | p = 0.0179 | p = 0.0130 | |
| p = 0.0336 | p = 0.0066 | p = 0.5546 | p = 0.0972 | |
| pT | r = −0.0856 | r = −0.2775 | r = −0.0068 | r = −0.1224 |
| p = 0.4559 | p = 0.0139 | p = 0.9527 | p = 0.2855 | |
| pN | r = 0.0408 | r = −0.0267 | r = 0.1116 | r = 0.0875 |
| p = 0.7230 | p = 0.8167 | p = 0.3092 | p = 0.4460 | |
| Tumor grading | r = −0.1741 | r = −0.1135 | r = 0.1159 | r = −0.0465 |
| p = 0.1275 | p = 0.3226 | p = 0.3121 | p = 0.6862 | |
| p = 0.1212 | p = 0.2360 | p = 0.3386 | p = 0.6862 | |
| Demographic data | ||||
| Age | r = 0.014 | r = −0.122 | r = 0.162 | r = 0.228 |
| p = 0.903 | p = 0.288 | p = 0.156 | p = 0.045 | |
| Sex (Female/Male) | p = 0.3038 | p = 0.6425 | p = 0.4046 | p = 0.4249 |
| Anatomical site of primary CRC | ||||
| Left-sided | p = 0.3784 | p = 0.6112 | p = 0.1338 | p = 0.7458 |
| Right-sided | ||||
| Histopathology | ||||
| Mucinous | p = 0.9794 | p = 0.6748 | p > 0.9999 | p = 0.3688 |
| Non-mucinous | ||||
| Macroscopic subtype | ||||
| Ulcerated | p = 0.1693 | p = 0.0152 | p = 0.3698 | p = 0.9482 |
| Non-ulcerated | ||||
| Tumor size ≤ 2 cm & > 2 cm | p = 0.9843 | p = 0.5237 | p = 0.0711 | p = 0.3661 |
| Tumor budding | p = 0.3038 | p = 0.6425 | p = 0.4046 | p = 0.4249 |
| Immune regulators | ||||
| Expression pattern | ||||
| Stromal | ||||
| PD-L1 | r = 0.320 | r = 0.316 | r = −0.036 | r = 0.172 |
| p = 0.0045 | p = 0.005 | p = 0.7566 | p = 0.1340 | |
| CD14 | r = 0.243 | r = 0.389 | r = −0.048 | r = 0.102 |
| p = 0.03308 | p = 0.00047 | p = 0.6758 | p = 0.3794 | |
| CD33 | r = 0.292 | r = 0.127 | r = −0.090 | r = 0.216 |
| p = 0.0096 | p = 0.2686 | p = 0.4308 | p = 0.0576 | |
| IL-2Rα | r = 0.245 | r = 0.093 | r = 0.256 | r = 0.331 |
| p = 0.032 | p = 0.423 | p = 0.025 | p = 0.003 | |
| Tumoral | ||||
| PD-L1 | r = 0.264 | r = 0.408 | r = −0.160 | r = 0.166 |
| p = 0.02 | p = 0.0002 | p = 0.1632 | p = 0.1488 | |
| CD14 | r = 0.116 | r = 0.371 | r = 0.014 | r = −0.006 |
| p = 0.315 | p = 0.001 | p = 0.901 | p = 0.958 | |
| CD33 | r = 0.327 | r = 0.102 | r = 0.050 | r = 0.134 |
| p = 0.003 | p = 0.376 | p = 0.662 | p = 0.244 | |
| IL-2Rα | r = 0.164 | r = 0.132 | r = 0.481 | r = 0.378 |
| p = 0.155 | p = 0.254 | p < 0.0001 | p = 0.001 | |
TNM tumor–node–metastasis classification, CRC colorectal cancer, PD-L1 Programmed cell death ligand-1, CD14 Cluster of differentiation 14, IL-2Rα interleukin-2 receptor alpha (CD25 antigen)
Bold values indicate statistical significance (α < 0.050)