Fig. 5. HFD or palmitic acid-rich diet (PAD) increases CRC growth in a TLR4-dependent manner in vivo.
The body weight of the xenograft mouse models that were inoculated with A wild-type HCT116 cells or B HCT116TLR4-KO cells, during the 18-day dietary intervention. The tumor volume of the xenograft mouse models that were inoculated with C wild-type HCT116 cells or D HCT116TLR4-KO cells, during the 18-day dietary intervention. E Pictures of the dissected tumor tissues. F The tumor weight of the xenograft mouse models that were inoculated with wild-type HCT116 cells or HCT116TLR4-KO cells, after the dietary intervention. HFD high-fat diet, CD matched control diet for HFD, PAD palmitic acid-rich diet, C-PAD matched control diet for PAD. Data are shown as means ± SEM, n = 3 mice in each group. *p < 0.05 compared with CD, #p < 0.05, ##p < 0.01 compared with C-PAD.