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. 2021 Aug 12;11:16438. doi: 10.1038/s41598-021-96064-6

Figure 3.

Figure 3

Clinical manifestations of CCR2-positive and CCR2-deficient SOD1G93A mice. (a) Median survival time, (b) rotarod test, (c) grip strength, (d) ALS-TDI score, and (e) area under the curve (AUC) of ALS-TDI scores measured from 7 to 17 weeks of age in (d). (f) Mean age of disease onset was defined as when mice reached peak body weight (CCR2-positive SOD1G93A mice, n = 24, and CCR2-deficient SOD1G93A mice, n = 18). The log-rank test was used to compare median survival time and onset time by body weight. Student’s t test was used for statistical comparisons of rotarod test and grip strength. The Mann–Whitney U-test was used for statistical comparisons of the AUC of the ALS-TDI scores. *p < 0.05; **p < 0.001.