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. 2021 Aug 13;345:113837. doi: 10.1016/j.expneurol.2021.113837

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Fig. 5 — ACE2 is expressed in brainstem aminergic nuclei. A) Schematic representation of the evaluated brainstem aminergic nuclei location in a sagittal section. B - D) ACE2 is expressed in tyrosine hydroxylase (TH) expressing neurons within the substantia nigra pars compacta (SNc, panel B) and ventral tegmental area (VTA, panel C) dopaminergic regions, as well as in the locus coeruleus (LC, panel D) noradrenergic region. E) Many tryptophan hydroxylase (TPH) neurons in the serotoninergic dorsal raphe (DR) nucleus were positive for ACE2 and co-expressed the glycine transporter 2 (GlyT2) and the calcium-binding protein calretinin (CR). Sparse TPH-positive neurons (indicated by the yellow arrow) do not express ACE2, CR, nor GlyT2. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)