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. 2021 Aug 12;12:4897. doi: 10.1038/s41467-021-24951-7

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Normalized Hi-C interaction map, high-confidence interactions (arc), CTCF-CTCF loops (arc), and CTCF loop domains (line) displayed on top of ChIP-seq profiles of CTCF and H3K27ac at chromosome 8q24.13 region. CTCF peaks are denoted by bars above the ChIP-seq profiles of CTCF. CTCF consensus motifs are denoted by red (forward orientation) and blue (reverse orientation) bars above the CTCF peaks. Normalized Hi-C interactions are shown as a heatmap with each pixel representing a 25 kb genomic region. The interaction significance (FDR) was calculated from Hi-C data. b Illustration of single-gene CTCF loop domains, multi-gene domains, and zero-gene domains. The numbers of domains in each group within HUES64 are displayed on top of each plot. c Display of a single-gene CTCF loop domain and the topologically isolated gene (TIG) at the EPHA2 locus. CTCF consensus motifs, ChIP-seq profiles of CTCF and H3K27ac, and normalized Hi-C interaction maps are displayed. CTCF peaks and enhancers are denoted by bars above the ChIP-seq profiles of CTCF and H3K27ac. CTCF consensus motifs are denoted by red (forward orientation) and blue (reverse orientation) bars above the CTCF peaks. Normalized Hi-C interactions are shown as a heatmap with each pixel representing a 10 kb genomic region. CTCF loop domains are displayed on the top and the interaction significance (FDR) was calculated from Hi-C data. d The distribution of the number of single-gene domains in the human genome by randomly shuffling the domain loci across the genome. The red line indicates the observed number of single-gene domains in the genome. e The distribution of the number of single-gene domains in the human genome by randomly shuffling the gene loci across the genome. The red line indicates the observed number of single-gene domains in the genome.