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. 2021 Aug 12;11:15166. doi: 10.1038/s41598-021-94157-w

Table 3.

Analysis of breathing during initial experimental conditions.

Dependent variable Comparison Estimate SE z p-value
V˙E (ln-transformed) R vs. U 0.27 0.03 11.17 < 0.0001
W1 vs. R − 0.14 0.03 − 4.58 < 0.0001
ΔFRC R vs. U − 0.35 0.01 − 32.67 < 0.0001
W1 vs. R 0.18 0.02 10.38 < 0.0001

The mixed-effects regression models used to test these contrasts accounted for a subject’s age, their BMI, and the experimental phase in the fixed effects, and included a random effect of subject identity to account for repeated measures (n = 911 breaths from 17 subjects in phases R, U, and W1). To appropriately model the variances, V˙E was ln-transformed, and the analysis for ΔFRC accounted for unequal variance across phases. The table provides test statistics for post-hoc contrasts of specific comparisons. U = initial standing upright measurement; R = unweighted prone measurement; W1 = first minute of weighted prone measurement.