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. 2021 Aug 12;12:4898. doi: 10.1038/s41467-021-24995-9

Fig. 7. Model of how PTC-3 and the loss thereof affects ER structure and LD formation.

Fig. 7

PTC-3 controls intracellular cholesterol levels directly by promoting its efflux. In the absence of PTC-3, cells accumulate cholesterol, which in turn directly influences membrane properties. In addition, cholesterol directly or indirectly affects NHRs, which subsequently leads to a reduction of acyl chain length and desaturation. This second effect enhances the changes in membrane properties and leads to changes in ER morphology and LD formation. ER endoplasmic reticulum, LD lipid droplet.