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. 2021 Aug 12;12:4877. doi: 10.1038/s41467-021-25181-7

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Fig. 2 — a, c WT mice maintained in C57BL/6NCrl background showed a well-developed SC and TM (*) at both 3 and 6 weeks of age. b Glis1-KO-C57BL/6NCrl eyes exhibit a morphologically mature ocular drainage tissue at 3 weeks of age. The histological assessment of the ocular angle at 3 weeks of age was performed on 6 WT and 6 Glis1-KO eyes with similar results within each group. In contrast, by 6 weeks of age Glis1-KO eyes exhibit a variable degree of focal TM degeneration, ranging from hypoplastic TM characterized by substantial thinning of the TM (d), reduction in the size of the Schlemm’s canal, and associated TM causing a partial collapse of the ocular drainage structures (e). f At 6 weeks of age a small proportion of mice (<10%) showed focal regions exhibiting partial or complete collapse of the ocular drainage structures lacking TM and Schlemm’s canal. a–f A magnified version of the image in the upper panel is shown in the lower panel. Arrows show edges of the SC. IV Iris vessel. The histological assessment of the ocular angle at 6 weeks of age was performed on 10 WT and 15 Glis1-KO eyes with similar results within each group. Scale bar = 50 μm. Detailed measurement of the TM area was performed on 5 eyes per experimental group, shown in Supplementary Figs. 5 and 6.