Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 12;11:16427. doi: 10.1038/s41598-021-95941-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Schematic representation depicting the regulation of Api5 following acetylation and deacetylation. (a) Model predicting the regulation of Api5 via the AMPK, Akt and p300 signalling cascade. (b) p300 acetylation of Api5 at lysine residue 251 stabilises the protein in the nucleus; whereas de-acetylation of Api5 at K251 by HDAC1 de-stabilises the protein which enables it to get translocated to the cytoplasm. Overall, this leads to proliferation of the cells.