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. 2021 Aug 12;12(8):789. doi: 10.1038/s41419-021-04073-0

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Four PDX models (PH423, PH341, PH370, and PH454) showed tumor reduction after paclitaxel treatments and four PDX models (PH747, PH778, PH397, and PH538) did not show tumor reduction after paclitaxel treatments. b–i CHAPS lysates of PDX samples PH423 (b), PH341 (c), PH370 (d), PH454 (e), PH747 (f), PH778 (g), PH397 (h), and PH538 (i) were immunoprecipitated (IP) with antibodies to BCLX_L, MCL1, or BCL2, and compared with serial dilutions of the input. Pull-downs with protein G beads only served as a negative control. j Relative tumor size as assessed by transabdominal ultrasound after treatment and % BAK bound to MCL1 are summarized for PDX samples in both the paclitaxel responsive group (purple numbers) and paclitaxel unresponsive group (blue numbers). The relative tumor size after treatment was calculated by (tumor area after treatment)/(tumor area before treatment). Relative tumor size ≤0.5 was defined as responsive and relative tumor size >1.0 was defined as unresponsive.