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. 2021 Aug 12;11:16378. doi: 10.1038/s41598-021-95839-1

Figure 5.

Figure 5

IL-34 upregulated the protein expression of IL-17A, IL-6, TNF-α, VEGF and HIF-1α in RA-FLSs. (A) Western blot images of IL-17A, IL-6, TNF-α, VEGF and HIF-1α protein levels in the IL-34 (0 ng/ml, 25 ng/ml, 50 ng/ml and 100 ng/ml) treatment groups. (B–F) The protein levels of IL-17A, IL-6, TNF-α, VEGF and HIF-1α in IL-34-treated (0 ng/ml, 25 ng/ml, 50 ng/ml and 100 ng/ml) RA-FLSs were analyzed by Western blotting. The differences between the four groups were tested by ANOVA. The data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs the 0 group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs the 25 group; ▲P < 0.05, ▲▲P < 0.01, ▲▲▲P < 0.001 vs the 50 group. ○P > 0.05 vs the 0 group.