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. 2021 Aug 12;11:16452. doi: 10.1038/s41598-021-95865-z

Table 4.

Accelerated failure time analysis (time ratios (TR) and 95% confidence intervals (CI)) for the association between oral health problems and respiratory mortality in older people in the BRHS after 9 years of follow-up and the HABC Study after 15 years of follow-up.

BRHS HABC study
Respiratory mortality Respiratory mortality
Age adjusted
TR (95% CI)
Fully adjusted*
TR (95% CI)
Age adjusted
TR (95% CI)
Fully adjusted
TR (95% CI)
Tooth loss Tooth loss
 ≥ 21 teeth (n = 594, 36%) 1.00 1.00  ≥ 21 teeth (n = 943, 48%) 1.00 1.00
15–20 teeth (n = 340, 20%) 0.76 (0.47, 1.23) 0.89 (0.53, 1.50) 15–20 teeth (n = 357, 18%) 0.87 (0.69, 1.11) 0.95 (0.74, 1.21)
8–14 teeth (n = 265, 16%) 0.72 (0.43, 1.18) 1.15 (0.60, 2.22) 8–14 teeth (n = 282, 14%) 0.86 (0.66, 1.12) 0.88 (0.68, 1.14)
1–7 teeth (n = 123, 7%) 0.46 (0.27, 0.78) 0.85 (0.41, 1.75) 1–7 teeth (n = 184, 9%) 0.76 (0.57, 1.02) 0.73 (0.54, 0.98)
0 teeth (n = 338, 20%) 0.56 (0.36, 0.87) 0.72 (0.44, 1.19) 0 teeth (n = 208, 10%) 0.74 (0.56, 0.97) 0.73 (0.55, 0.97)
Periodontal disease||(% of sites with loss of attachment > 5.5 mm) Periodontal disease||(% of sites with loss of attachment ≥ 3 mm)
 ≤ 20% (n = 943, 76%) 1.00 1.00  ≤ 20% (n = 412, 36%) 1.00 1.00
 > 20% (n = 303, 24%) 0.85 (0.59, 1.23) 1.04 (0.65, 1.64)  > 20% (n = 721, 64%) 0.83 (0.65, 1.07) 0.90 (0.70, 1.16)
Self-rated oral health Self-rated oral health
Good/excellent (n = 1320, 65%) 1.00 1.00 Good/excellent (n = 1889, 70%) 1.00 1.00
Fair/poor (n = 719, 35%) 0.85 (0.66, 1.09) 1.02 (0.71, 1.45) Fair/poor (n = 829, 30%) 0.87 (0.75, 1.02) 0.97 (0.83, 1.14)
Dry mouth symptoms Dry mouth
0 (n = 762, 37%) 1.00 1.00 No (n = 2612, 96%) 1.00 1.00
1–2 (n = 666, 33%) 0.89 (0.66, 1.21) 1.05 (0.71, 1.55) Yes (n = 107, 4%) 0.71 (0.52, 0.96) 0.75 (0.55, 1.02)
 ≥ 3 (n = 606, 30%) 0.84 (0.62, 1.12) 1.24 (0.81, 1.90)
Cumulative oral health problems Cumulative oral health problems§
0 (n = 340, 16%) 1.00 1.00 0 (n = 778, 28%) 1.00 1.00
1 (n = 1041, 49%) 0.61 (0.39, 0.96) 0.93 (0.56, 1.54) 1 (n = 1367, 49%) 0.79 (0.65, 0.96) 0.85 (0.70, 1.03)
2 (n = 540, 25%) 0.65 (0.40, 1.04) 1.11 (0.62, 1.96) 2 (n = 394, 14%) 0.70 (0.55, 0.90) 0.77 (0.61, 0.97)
 ≥ 3 (n = 226, 10%) 0.65 (0.38, 1.12) 1.38 (0.64, 3.00)  ≥ 3 (n = 223, 8%) 0.64 (0.49, 0.84) 0.76 (0.58, 1.01)

*Age, social class, smoking, alcohol, physical activity, history of CVD and diabetes, BMI, EDI score, FEV1/FVC ratio, hypertension, triglycerides, HDL, CRP, IL-6, fibrin d-dimer, hsTnT.

Age, gender, race, education, smoking, alcohol, physical activity, history of CVD and diabetes, BMI, HEI score, respiration rate, hypertension, total blood cholesterol, CRP, IL-6.

Includes < 21 teeth, difficulty eating, symptoms of dry mouth, and sensitivity to hot/cold/sweet.

§Includes < 21 teeth, difficulty eating, dry mouth when eating, and limit of food due to gum problems. ||Only measures of periodontal disease with positive associations included.