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. 2021 Aug 12;11:16430. doi: 10.1038/s41598-021-95799-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Alternative colorimetric detection based on the complex murexide-zinc. (A) A strong color change from yellow to pink is observed when pyrophosphate (PPi) is added to a solution containing Zn-MX. Tenfold dilutions of in vitro transcribed (IVT) viral IVT RNA (Ngene) were amplified via RT-LAMP and detected using phenol red (B) or Zn-MX (C). Amplification was confirmed by agarose gel electrophoresis (AGE). Saliva samples of a healthy donor (HD) and of nine COVID-19 patients were analyzed by RT-LAMP followed by detection with Zn-MX (D) or phenol red (E) and amplification was confirmed by AGE (Original gel images in Fig. S1).