Table 2.
Multivariable hazard ratios and 95% confidence intervals of disability dementia according to quartiles of total tocopherol, α-, β-, γ- and δ-tocopherol intakes.
| Q1 | Q2 | Q3 | Q4 | Trend P | |
|---|---|---|---|---|---|
| Total tocopherol | |||||
| Person-years | 14,363 | 14,974 | 14,980 | 15,365 | |
| Number of cases | 178 | 179 | 168 | 145 | |
| Model 1 | 1.00 | 0.99 (0.81–1.22) | 0.93 (0.75–1.16) | 0.79 (0.63–1.00) | 0.04 |
| Model 2 | 1.00 | 1.01 (0.82–1.25) | 0.95 (0.77–1.18) | 0.79 (0.63–1.00) | 0.05 |
| Model 3 | 1.00 | 0.89 (0.71–1.12) | 0.74 (0.56–0.98) | 0.50 (0.34–0.74) | 0.001 |
| Model 4 | 1.00 | 0.97 (0.78–1.22) | 0.88 (0.67–1.16) | 0.69 (0.47–1.01) | 0.05 |
| α-Tocopherol | |||||
| Person-years | 14,480 | 15,011 | 15,023 | 15,167 | |
| Number of cases | 177 | 148 | 175 | 170 | |
| Model 1 | 1.00 | 0.73 (0.59–0.91) | 0.89 (0.72–1.10) | 0.79 (0.64–0.99) | 0.16 |
| Model 2 | 1.00 | 0.74 (0.59–0.93) | 0.91 (0.74–1.14) | 0.81 (0.65–1.02) | 0.19 |
| Model 3 | 1.00 | 0.74 (0.59–0.92) | 0.90 (0.72–1.13) | 0.80 (0.62–1.03) | 0.25 |
| Model 4 | 1.00 | 0.75 (0.60–0.94) | 0.94 (0.66–1.18) | 0.85 (0.66–1.09) | 0.53 |
| β-Tocopherol | |||||
| Person-years | 14,742 | 15,118 | 14,865 | 14,957 | |
| Number of cases | 187 | 172 | 161 | 150 | |
| Model 1 | 1.00 | 1.03 (0.84–1.27) | 0.91 (0.73–1.13) | 0.94 (0.76–1.17) | 0.39 |
| Model 2 | 1.00 | 1.04 (0.84–1.28) | 0.92 (0.74–1.15) | 0.93 (0.74–1.16) | 0.48 |
| Model 3 | 1.00 | 1.02 (0.82–1.27) | 0.90 (0.70–1.14) | 0.88 (0.66–1.18) | 0.28 |
| Model 4 | 1.00 | 1.07 (0.86–1.33) | 0.97 (0.76–1.24) | 1.00 (0.75–1.34) | 0.85 |
| γ-Tocopherol | |||||
| Person-years | 14,493 | 14,972 | 14,884 | 15,333 | |
| Number of cases | 186 | 163 | 174 | 147 | |
| Model 1 | 1.00 | 0.91 (0.74–1.12) | 0.97 (0.78–1.19) | 0.87 (0.70–1.09) | 0.34 |
| Model 2 | 1.00 | 0.92 (0.74–1.14) | 0.97 (0.79–1.20) | 0.86 (0.68–1.08) | 0.39 |
| Model 3 | 1.00 | 0.85 (0.67–1.08) | 0.83 (0.63–1.11) | 0.64 (0.42–0.99) | 0.06 |
| Model 4 | 1.00 | 0.95 (0.75–1.20) | 1.03 (0.77–1.38) | 0.95 (0.62–1.46) | 0.92 |
| δ-Tocopherol | |||||
| Person-years | 14,572 | 14,740 | 15,210 | 15,160 | |
| Number of cases | 175 | 161 | 169 | 165 | |
| Model 1 | 1.00 | 0.93 (0.75–1.15) | 0.90 (0.73–1.11) | 0.86 (0.69–1.07) | 0.16 |
| Model 2 | 1.00 | 0.92 (0.74–1.13) | 0.90 (0.73–1.11) | 0.83 (0.67–1.04) | 0.14 |
| Model 3 | 1.00 | 0.88 (0.70–1.10) | 0.83 (0.66–1.06) | 0.73 (0.55–0.99) | 0.04 |
| Model 4 | 1.00 | 0.92 (0.74–1.15) | 0.91 (0.72–1.15) | 0.85 (0.64–1.14) | 0.28 |
Model 1: Adjusted for age and sex, and stratified by area.
Model 2: Multivariable model adjusted further for energy, smoking status, and DHA + EPA.
Model 3: Multivariable model adjusted further for variables in model 2 and α-linolenic acid.
Model 4: Multivariable model adjusted further for variables in model 2 and linoleic acid.