Table 2.
Characteristics and selection criteria for the eleven genes further subjected to validation experiments: identification as LCG, present in a specific network; identification as obesity and type 2 diabetes-related genetic variant (SNP) and differential hepatic expression between chow and HFD mice (log2FC and p).
| Gene | LCG | Network | SNP | log2FC | p adjusted |
|---|---|---|---|---|---|
| Arhgap24 | yes | HFD | no | 0.99 | 0.02 |
| Cd82 | yes | HFD | no | 0.5 | 0.03 |
| Gk | yes | HFD | no | 0.73 | 0.01 |
| Inhbe | yes | HFD | yes | 1.2 | 0.02 |
| Myc | yes | HFD | no | −1.31 | 0.04 |
| Rapgef4 | yes | HFD | no | −1.23 | <0.00 |
| Smim13 | yes | HFD | no | −0.89 | 0.01 |
| Ddx3x | yes | Chow | no | −0.6 | 0.01 |
| Cobll1 | yes | HFD | yes | −0.33 | 0.24 |
| Appl2 | yes | HFD | yes | 0.63 | 0.15 |
| Tap1 | no | Chow/HFD | no | 1.04 | <0.00 |