Table 5.
Effect of dihydroartemisinin (DHA) on the concentrations of intestinal inflammatory cytokines in weaned piglets with intrauterine growth retardation (IUGR).
| Item | Treatment1 |
P-value |
|||
|---|---|---|---|---|---|
| NBW-CON | IUGR-CON | IUGR-DHA | NBW-CON vs. IUGR-CON | IUGR-CON vs. IUGR-DHA | |
| Jejunum | |||||
| IL-1β, ng/g protein | 33.61 ± 3.21 | 54.08 ± 3.00∗ | 40.44 ± 1.65# | <0.001 | 0.008 |
| IL-6, ng/g protein | 64.73 ± 3.40 | 83.68 ± 2.96∗ | 62.67 ± 3.63# | 0.005 | 0.002 |
| TNF-α, ng/g protein | 17.93 ± 0.68 | 22.13 ± 1.13∗ | 20.11 ± 1.12 | 0.024 | 0.350 |
| Ileum | |||||
| IL-1β, ng/g protein | 26.68 ± 1.86 | 33.66 ± 1.71∗ | 26.59 ± 1.71# | 0.037 | 0.032 |
| IL-6, ng/g protein | 56.67 ± 3.05 | 72.24 ± 2.55∗ | 60.91 ± 2.73# | 0.003 | 0.029 |
| TNF-α, ng/g protein | 15.13 ± 1.29 | 16.76 ± 0.62 | 13.14 ± 0.63# | 0.433 | 0.032 |
IL-1β = interleukin 1β; IL-6 = interleukin 6; TNF-α = tumor necrosis factor α.
∗, a significant difference (P < 0.05) between NBW-CON group and IUGR-CON group; #, a significant difference (P < 0.05) between IUGR-DHA group and IUGR-CON group.
1
NBW-CON, normal body weight group fed a basal diet; IUGR-CON, IUGR group fed a basal diet; IUGR-DHA, IUGR group fed a diet supplemented with DHA at 80 mg/kg. Results were showed as means ± SEM (n = 8).