Table 3.

Inflammatory parameters after infusion of CD45RA- memory T cells. NR: normal range. N/D: Not determined; *data are from time to hospitalization.

	Dose Cohort
	1 × 105 cells/kg			5 × 105 cells/kg			1 × 106 cells/kg
Laboratory findings	#1	#2	#3	#4	#5	#6	#7	#8	#9	#10*
C-reactive protein, mg/L (NR 0–5)
Day of infusion	68.9	67.7	222.7	109.4	63	90.9	<0.05	85	24.9	274.3
Day 2 post infusion	40.4	18.2	127.8	95.2	35.2	66.2	1.2	4.6	22.8	227.4
Day 6 post infusion	10.6	55.2	44.6	13	9.9	9.8	<0.5	5.1	3.2	208.6
Day 13 post infusion	1.5	2.3	2.4	<0.5	N/D	N/D	N/D	N/D	<0.5	173.1
Fibrinogen, mg/dl (NR 150–450)
Day of infusion	490	598	>1200	778	541	600	598	789	807	1103
Day 2 post infusion	507	394	1117	722	408	607	703	488	589	1004
Day 6 post infusion	388	519	860	372	440	498	430	415	429	>1200
Day 13 post infusion	430	334	421	217	N/D	N/D	N/D	N/D	410	N/D
Ferritin, ng/ml (NR 10–291)
Day of infusion	1563	705	1712	468	304	111	206	497	582	N/D
Day 2 post infusion	1527	687	1392	690	283	109	254	327	343	695
Day 6 post infusion	1351	528	980	509	204	60	253	408	279	970
Day 13 post infusion	1139	419	625	333	N/D	N/D	N/D	N/D	250	865
D-Dimer, ng/ml (NR 0–500)
Day of infusion	1590	320	820	1470	540	670	300	870	440	510
Day 2 post infusion	1590	230	1710	1940	320	910	650	1050	440	440
Day 6 post infusion	1200	200	820	5090	660	670	310	570	200	1700
Day 13 post infusion	600	N/D	420	2340	N/D	N/D	N/D	N/D	330	830
IL-6, pg/ml (NR < 3,4)
Day of infusion	2.6	25.6	N/D	58.3	66.2	N/D	N/D	25.6	0.7	N/D
Day 2 post infusion	2.6	10.9	131	66.6	7.1	33	29.3	6.5	1.7	N/D
Day 6 post infusion	2.7	<2	21.5	202	10.6	N/D	17.3	N/D	<2.7	12.1
Day 13 post infusion	N/D	N/D	2.8	59.8	N/D	N/D	N/D	N/D	<2.7	12.2