Table 4.
Donor chimerism after infusion of CD45RA- memory T cells from the convalescent donor. The indicated chimerism values were obtained as the mean value of the analysis of two different INDEL systems. Pre-infusion patient samples were analysed, and results were employed as negative background control. The data are shown by weeks after infusion.
| Dose cohort |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| Variables | 1 × 105 cells/kg |
5 × 105 cells/kg |
1 × 106 cells/kg |
||||||
| Donor Chimerism (%) | #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9 |
| D0-D7 | 0.011 | 1.445 | 0.405 | 0.065 | 0.023 | 0.192 | 0.989 | 0.450 | <0.01 |
| D7-D14 | <0.01 | 0.310 | <0.01 | 0.097 | 0.185 | 0.086 | 3.090 | 0.163 | 0 |
| D14–21 | 0.084 | 0.163 | <0.01 | 0.135 | <0.01 | <0.01 | <0.01 | <0.01 | 0.2 |
| D21–28 | N/D | N/D | N/D | N/D | N/D | N/D | N/D | N/D | 0.011 |