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In lung adenocarcinoma, CADM1 participates in the Hippo pathway, thereby regulating cell proliferation and contact inhibition. CADM1 forms a scaffold protein complex with NF2, KIBRA, SAV1, etc., recruits MST1/2 and LATS1/2 kinases to the cell membrane to activate the Hippo pathway, and then moves to the cytoplasm or nucleus after phosphorylation to inactivate YAP1 and inhibit the transcription of its target genes, thereby inhibiting cell proliferation.
