TABLE 2.
Summary of the function and regulatory factor/pathway for CADM1 in cutaneous malignancies.
| Cancer type | Property | Function | Regulatory factor/pathway |
| Ovarian cancer | Suppressor | Colony formation, apoptosis | PI3K/AKT/mTOR, ROS/JNK, Rap1A, EDN1 |
| Proliferation, invasion, migration | |||
| Cervical cancer | Suppressor | Invasion, migration, angiogenesis | miR-205, AKT, VEGF, IL-8 |
| Tumorigenesis | |||
| Malignant melanoma | Suppressor | Invasion, migration, EMT | TWIST1, miR-214, MMP-2/9, Linc01296 |
| Cell viability, tumorigenesis | RAS, RAF, MEK, ERK1/2 | ||
| Nasopharyngeal carcinoma | Suppressor | Invasion, proliferation | FRα, ERK1, ERK2 |
| Osteosarcoma | Suppressor | Proliferation, invasion, migration | miR-214-3P, P44/42, MAPK |
| Pancreatic cancer | Suppressor | Apoptosis, proliferation | miR-196b |
| Non-small cell lung cancer | Suppressor | Apoptosis, proliferation, invasion | YAP1, MST1/2, LATS1/2, Hippo, miR-423-5p |
| Migration, vascular permeability | HER2, STAT3 | ||
| Colorectal cancer | Suppressor | Tumorigenesis, invasion | c-Src, cbp |
| Gastric cancer | Suppressor | Proliferation, invasion, migration | LncCAMD1-AS1, miR-126 |
| Hepatocellular carcinoma | Suppressor | Invasion, migration, angiogenesis | PTEN,AKT,GSK-3β,Rb,E2F |
| Tumorigenesis | Wint, miR-1246/10b/194/873/155 | ||
| Breast cancer | Suppressor | Proliferation, invasion, migration | miR-155-3p, DAL-1/4.1B |
| Apoptosis | |||
| Neuroblastoma | Suppressor | Invasion, migration | MET-75, SPHK1 |
| Glioblastoma | Suppressor | Invasion, migration, proliferation | LncCAMD1-AS1, miR-148a, STAT3 |
| Prostate cancer | Suppressor | Invasion, migration | ANXA1 |
| Bladder Cancer | Suppressor | Invasion, migration, proliferation | Caspase-3, Bax, EMT |
| Apoptosis | |||
| Squamous cell carcinoma | Suppressor | Invasion, migration, proliferation | STAT3, HER2, P14, miR-424-5p |
| Apoptosis, EMT | |||
| Clear cell renal cell carcinoma | Suppressor | Migration, apoptosis, cell growth | LncCADM1-AS1 |
| Gallbladder cancer | Suppressor | Migration, proliferation, EMT | miR-10b, TGF-β, miR-182 |
| Kaposi’s sarcoma | Oncogene | Proliferation, tumorigenesis | VFLIP, VGPCR, NF-κB. NEMO |
| Adult T-cell leukemia/lymphoma | Oncogene | Cell growth, invasion, self-aggregation | HTLE-1, Tax, NF-κB, P47 |
| Endothelial cell adhesion | |||
| Small cell lung cancer | Oncogene | Proliferation, tumorigenesis | 4.1R |
| Merkel cell carcinoma | Oncogene | Infiltration | / |
| Mycosis fungoides | Oncogene | Infiltration | / |
| Sezary syndrome | Oncogene | Infiltration | / |