Table 1.
Demographics of ADNI participants stratified by baseline diagnosis
| CN (N = 370) | SMC (N = 95) | EMCI (N = 271) | LMCI (N = 491) | AD (N = 304) | P-value | |
|---|---|---|---|---|---|---|
| Age | 74.6 (5.8) | 72.3 (5.7) | 71.3 (7.6) | 74.0 (7.6) | 74.8 (7.8) | 2.6 × 10−9 |
| Sex: (Male/Female) | 181/189 | 40/55 | 149/122 | 299/192 | 166/138 | 9.2 × 10−4 |
| Education, years | 16.3 (2.8) | 16.7 (2.6) | 16.0 (2.7) | 15.8 (2.9) | 15.2 (3.0) | 1.3 × 10−6 |
| BMI (Kg/M2) | 27.0 (4.5) | 28.4 (6.2) | 28.0 (5.4) | 26.4 (4.3) | 25.9 (4.7) | 2.9 × 10−8 |
| APOE ε4 (0/1/2) | 266/95/9 | 66/28/1 | 156/96/19 | 224/201/66 | 106/139/59 | <1 × 10−15 |
| Amyloid positivity (−/+) | 114/53 | 49/26 | 137/130 | 49/97 | 15/113 | <1 × 10−15 |
| Amyloid PET SUVR | 1.11 (0.17) | 1.12 (0.18) | 1.18 (0.21) | 1.28 (0.24) | 1.39 (0.22) | <1 × 10−15 |
| Memory composite | 1.03 (0.57) | 1.08 (0.54) | 0.58 (0.60) | −0.08 (0.62) | −0.85 (0.54) | <1 × 10−15 |
| Executive function composite | 0.78 (0.79) | 0.79 (0.85) | 0.50 (0.85) | 0.01 (0.86) | −0.90 (0.93) | <1 × 10−15 |
| MMSE | 29.1 (1.1) | 29.0 (1.2) | 28.3 (1.60) | 27.1 (1.83) | 23.3 (2.0) | <1 × 10−15 |
| C3 | −0.02 (1.01) | −0.06 (0.73) | −0.15 (0.91) | −0.04 (0.90) | −0.23 (0.93) | 1.9 × 10−3 |
| Kynurenine | −0.08 (0.98) | −0.31 (0.87) | −0.32 (0.88) | −0.12 (0.96) | −0.24 (1.04) | 5.1 × 10−3 |
| LysoPC a C18:2 | 0.17 (0.96) | −0.11 (0.89) | 0.04 (0.92) | 0.37 (0.97) | 0.27 (0.92) | 3.4 × 10−7 |
| PC aa C42:0 | 0.11 (0.98) | 0.01 (1.01) | 0.01 (0.90) | 0.26 (0.95) | 0.24 (0.91) | 1.4 × 10−3 |
| PC ae C42:3 | 0.44 (0.91) | 0.17 (1.00) | 0.27 (0.95) | 0.49 (0.91) | 0.40 (0.92) | 2.5 × 10−3 |
| PC ae C44:3 | 0.34 (0.92) | 0.28 (0.97) | 0.07 (0.91) | 0.45 (0.93) | 0.41 (0.94) | 3.1 × 10−6 |
| PC ae C44:4 | 0.28 (0.95) | 0.12 (0.96) | 0.17 (0.99) | 0.46 (0.93) | 0.45 (0.91) | 1.3 × 10−5 |
| PC ae C44:5 | 0.15 (1.01) | 0.02 (0.94) | 0.09 (1.01) | 0.30 (0.94) | 0.32 (0.90) | 1.2 × 10−3 |
| PC ae C44:6 | 0.13 (1.00) | −0.03 (0.96) | 0.06 (0.94) | 0.34 (0.94) | 0.31 (0.92) | 1.7 × 10−5 |
Data are reported as mean (SD) unless otherwise indicated.
AD, Alzheimer’s disease; ADAS-Cog 13, modified 13-item Alzheimer’s Disease Assessment Scale, cognitive subscale; BMI, Body mass index; CDR-SB, Clinical Dementia Rating-Sum of Boxes; CN, cognitively normal older adults; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; SMC, subjective memory complaint; MMSE, Mini-Mental State Examination.