Table 1.

Participant inclusion and exclusion criteria

	Inclusion criteria	Exclusion criteria*
Index cases	• Provided a signed and dated informed consent form • Aged 18 to < 80 years of age • Confirmed SARS-CoV-2 diagnosis by PCR within 72 h of first treatment dose • The first known diagnosis in the household • Not currently enrolled in a clinical trial and agree to not take any other investigational treatments over the next 28 days • Must plan to remain resident in the household during the study • Lives in household with at least one other ‘treatment-eligible household contact	• Inability to take medications orally or by injection • Known sensitivity/allergy to interferons or use of interferons for another indication • Known adverse drug-drug interactions with any study drugs • Malignancy • Known clinical immune deficiency • Pregnancy or unwillingness of female participant of childbearing age to use recognized methods of birth control/contraception during the trial period • Retinopathy • Known grade 4 or 5 chronic kidney or liver disease • Known arrhythmias • Known autoimmune disease or chronic inflammatory disease • Chronic liver disease • Hospitalization for depression in the last 3 months • Current suicidal ideation • Previous therapeutic use of IFN
Treatment eligible contact	• Provided a signed and dated informed consent form • Aged 18 to < 80 years of age • Not currently enrolled in a clinical trial and agree to not take any other investigational treatments over the next 28 days • Must plan to remain resident in the household during the study • No history of previously confirmed SARS-CoV-2 diagnosis
Treatment ineligible contact	• Provided a signed and dated informed consent form, parental informed consent, and assent if applicable • Under 18 years OR ≥ 80 years of age OR aged 18 to < 80 years with any contraindication for IFN treatment listed in ‘exclusion criteria’ • Not currently enrolled in a clinical trial and agree to not take any other investigational treatments over the next 28 days • Must plan to remain resident in the household during the study • No history of previously confirmed SARS-CoV-2 diagnosis

^*All household members are ineligible if participation by any member is declined or if the index case has been in complete self-quarantine from other household members during the 48 h prior to diagnosis of SARS-CoV-2 infection