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. 2021 Jul 30;12:697483. doi: 10.3389/fphar.2021.697483

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Copyright © 2021 Li, Zeng, Xu, Huang, Tao, Li, Zhang, Chen, Xia, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OA decreases eWAT inflammation level and ratio of M1/M2 ATMs in DIO mice. (A) ATMs associated markers in eWAT (n = 5). (B) WB of phosphorylated p38 MAPK (p-p38 MAPK), phosphorylated JNK (p-JNK), phosphorylated ERK (p-ERK), and their total proteins in eWAT of mice. (C–F) FCM analysis of the SVF of eWAT and iWAT of mice (n = 5). (C, E) Representative plots of FCM analysis: proportion of M1 or M2 macrophages to ATMs. (D, F) Statistics of FCM analysis. Data are percentages of M1 ATMs, percentages of M2 ATMs, and M1/M2 ratios. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.