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. 2021 Jul 30;12:697483. doi: 10.3389/fphar.2021.697483

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Copyright © 2021 Li, Zeng, Xu, Huang, Tao, Li, Zhang, Chen, Xia, Li and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OA decreases the expression of VDAC, the activation of NLRP3 inflammasome and the production of mitochondrial ROS in vitro and/or in vivo. (A) WB of VDAC, Caspase-1, IL-1β in eWAT of mice. (B) qPCR results of Caspase-1, IL-1β and IL-18 in eWAT (n = 5). (C) WB of VDAC, Caspase-1 in RAW264.7 macrophages. (D) qPCR results of Caspase-1, IL-1β and IL-18 in RAW264.7 macrophages (n = 3). (E) Fluorescence staining of mitochondrial ROS in RAW264.7 macrophages. (F) Fluorescence intensity of MitoSOX analyzed by FCM in RAW264.7 macrophages (n = 3–4). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. vehicle or control incubations, ^† p < 0.05, ^†† p < 0.01, ^††† p < 0.001, ^†††† p < 0.0001 vs. IFN-γ/LPS stimulated incubations.