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. 2021 Jul 30;13:709620. doi: 10.3389/fnagi.2021.709620

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Copyright © 2021 Ryu, Iwashita, Lee, Uchimura and Kosodo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The transition of CSPGs in the DG during maturation and the shift in stiffness by CSPG manipulation. (A) Representative immunostaining images for CSPGs using CS-56 antibody (green) and DAPI (blue) at various postnatal stages. The white-dotted lines represent the border between the GCL and SGZ+HL area. Scale bar: 200 μm. (B) The bar graph with plots presents a quantitative analysis of the immunoreactivity of the CSPGs in the GCL and SGZ+HL area (blue-square plots: GCL; magenta-triangle plots: SGZ+HL). (C) The bar graph with plots presents a quantitative analysis of the stiffness in the GCL and SGZ+HL area treated with chABC (blue-square plots: GCL; magenta-triangle plots: SGZ+HL). (D) The bar graph with plots presents a quantitative analysis of the stiffness in the GCL and SGZ+HL area treated with CS. Final concentrations supplied in the buffer are indicated. *p < 0.05, ***p < 0.001.