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. 2021 Aug 13;19:347. doi: 10.1186/s12967-021-03034-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — TFRC is associated with suppressive tumor immune microenvironment and poor prognosis for HCC. A TFRC mRNA expression in 33 types of TCGA tumors. B Kaplan–Meier curves for overall survival stratified according to high and low TFRC expression in TCGA LIHC database. C The relative percent of 22 types of immune cells in each LIHC sample (n = 366). D Scatter plot showing positive correlation of TFRC expression and infiltration level of M2-macrophages but not M1-macrophages in TCGA LIHC database. E The fraction of 22 types of immune cells in the Low- and High-TFRC group, respectively. Median TFRC expression serves as the cut-off to divide HCC patients into Low- and High-TFRC groups. F Correlation between TFRC and M1/M2 signature genes. Color depth and circle square represent the degrees of correlation. **p < 0.01, ***p < 0.001