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. 2021 Jul 1;60(32):17378–17382. doi: 10.1002/anie.202105004

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© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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ToF‐SIMS images display the distribution of lipid headgroup fragments in fly brain sections of control (left column) and modafinil‐treated (right column) flies analyzed with ToF‐SIMS. A),B) Ion images of the PC and SM head group at m/z 184.1 in the positive ion mode; C),D) PC fragment at m/z 224.1 in the positive ion mode; and E)–H) PE fragments at m/z 140.0 and 180.1 in the negative ion mode. All the images were recorded with the ToF.SIMS V instrument equipped with 25 keV Bi₃ ⁺⁺ as a primary ion beam. The primary ion beam current was 0.3 pA and the total ion dose was 2×10¹² ions cm⁻².