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. 2021 Jul 30;12:695779. doi: 10.3389/fphys.2021.695779

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Copyright © 2021 Selli, Kuzmiszyn, Smaglyukova, Kondratiev, Fuskevåg, Lyså, Ravna, Tveita, Sager and Dietrichs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Temperature-dependent inhibition of phosphodiesterase-3 (PDE3) by vardenafil and sildenafil. (A) Sildenafil inhibition curves for PDE3-activity at temperatures ranging from 37°C to 20°C. The doses of sildenafil are in logarithm of the concentration in mol/L. (B) Inhibition curves for PDE3-activity by sildenafil in % of normothermic inhibition curve at temperatures ranging from 37°C to 20°C. The doses of sildenafil are in logarithm of the concentration in mol/L. (C) Vardenafil inhibition curves for PDE3-activity at temperatures ranging from 37°C to 20°C. The doses of vardenafil are in logarithm of the concentration in mol/L. (D) Inhibition curves for PDE3-activity by vardenafil in % of normothermic inhibition curve at temperatures ranging from 37°C to 20°C. The doses of vardenafil are in logarithm of the concentration in mol/L.