Figure 6.

Therapeutic performance of photosensitizer loaded AIE‐polymersomes (AIE‐BPP) in subcutaneous A549 lung tumor‐bearing nude mice. a) The mice treated with BPP photosensitizer‐loaded AIE‐polymersomes (AIE‐BPP) (8 mg kg⁻¹ AIE‐Ps, 0.9 mg kg⁻¹ BPP) displayed a more pronounced antitumor effect compared with the PBS group and other negative controls. b) Tumor weight separated from the mice after the treatment, in which BPP loaded AIE‐polymersomes (AIE‐BPP) group, displayed a minimum tumor weight compared with the other groups. c) After treatment with PBS, the negative controls, and the AIE‐BPP with light irradiation, the mice all still retained comparable body weight. d) Typical TUNEL staining of tumor sections excised from the tumor‐bearing mice following 18 days of treatment with different formulations, apoptotic cells were stained by TUNEL (green) and the nucleus was stained with DAPI (blue), scale bar: 100 μm. Significance was assessed using one‐way ANOVA, followed by Tukey's multiple comparisons test (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001).