TABLE 2.
Adjusted means of metabolites that differed across diagnostic groups (at q<.05) in ANCOVAs
| Metabolites | Healthy controls | Remitted depressive or anxiety disorder | Current pure anxiety disorder | Current pure depressive disorder | Current comorbid depressive and anxiety disorder | p (ANCOVA) |
|---|---|---|---|---|---|---|
| Name (units) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | |
| Glycoprotein acetyls (mmol/L) | 1.34 (1.33–1.36) | 1.33 (1.32–1.35) | 1.34 (1.32–1.36) | 1.38 (1.36–1.41) | 1.37 (1.35–1.39) | 1.15E−16 |
| Docosahexaenoic acid, 22:6 (mmol/L) | 0.14 (0.13–0.14) | 0.14 (0.13–0.14) | 0.14 (0.13–0.14) | 0.12 (0.12–0.13) | 0.12 (0.12–0.13) | 6.59E−08 |
| Serum total triglycerides (mmol/L) | 1.21 (1.16–1.27) | 1.18 (1.13–1.23) | 1.19 (1.13–1.24) | 1.28 (1.21–1.35) | 1.23 (1.18–1.29) | 2.04E−07 |
| Omega‐3 fatty acids (mmol/L) | 0.38 (0.37–0.40) | 0.38 (0.37–0.39) | 0.39 (0.37–0.40) | 0.36 (0.35–0.38) | 0.36 (0.35–0.37) | 7.29E−07 |
| Triglycerides in VLDL (mmol/L) | 0.85 (0.81–0.90) | 0.84 (0.79–0.88) | 0.84 (0.80–0.89) | 0.91 (0.85–0.97) | 0.87 (0.82–0.92) | 9.02E−07 |
| Apolipoprotein B (g/L) | 0.95 (0.93–0.98) | 0.95 (0.93–0.97) | 0.95 (0.93–0.97) | 0.98 (0.96–1.01) | 0.97 (0.95–0.99) | 3.19E−05 |
| Mean diameter for VLDL particles (nm) | 36.59 (36.46–36.72) | 36.56 (36.44–36.67) | 36.61 (36.47–36.74) | 36.73 (36.57–36.88) | 36.63 (36.50–36.76) | 3.34E−05 |
| VLDL cholesterol (mmol/L) | 0.86 (0.83–0.88) | 0.87 (0.84–0.89) | 0.86 (0.83–0.89) | 0.89 (0.86–0.93) | 0.87 (0.85–0.90) | 1.23E−04 |
| Glucose (mmol/L) | 4.35 (4.28–4.42) | 4.27 (4.21–4.33) | 4.32 (4.26–4.39) | 4.36 (4.28–4.44) | 4.35 (4.28–4.42) | 1.73E−04 |
| Acetoacetate (mmol/L) | 0.04 (0.04–0.05) | 0.04 (0.03–0.04) | 0.04 (0.04–0.04) | 0.04 (0.04–0.05) | 0.04 (0.04–0.05) | 2.62E−03 |
| Remnant cholesterol (mmol/L) | 1.57 (1.53–1.61) | 1.59 (1.55–1.63) | 1.58 (1.54–1.62) | 1.62 (1.57–1.67) | 1.60 (1.56–1.64) | 3.64E−03 |
| Estimated degree of unsaturation | 1.22 (1.21–1.23) | 1.22 (1.21–1.22) | 1.22 (1.21–1.23) | 1.22 (1.21–1.23) | 1.22 (1.21–1.22) | 6.65E−03 |
| Total phosphoglycerides (mmol/L) | 1.87 (1.83–1.91) | 1.89 (1.86–1.93) | 1.88 (1.84–1.92) | 1.85 (1.80–1.90) | 1.85 (1.81–1.89) | 8.82E−03 |
Means of the 13 metabolites variables that differed across groups at a significance level of false discovery rate <5% in ANCOVAs. The second to fifth column contain means adjusted for age, sex, smoking status, fasting status, years of education, number of somatic diseases, and BMI. The rightest column contains the raw p values obtained by ANCOVAs. Results of all forty tested metabolites can be found in Table S3.