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. 2021 Aug 13;16:56. doi: 10.1186/s13027-021-00397-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — HPV16 E6 upregulated miR-27a-3p via DGCR8 and miR-27a-3p improves radiosensitivity in HNSCC. a The relative mRNA expression level of DGCR8 in DGCR8 overexpressing/knockdown HNSCC cell lines. b, c The relative expression level of miR-27a-3p in DGCR8 overexpressing/knockdown HNSCC cell lines. d The relative mRNA expression level of miR-27a-3p in E6-overexpressing HNSCC cell lines with/without DGCR8 knockdown or in DGCR8 overexpressing HNSCC cell lines with/without E6 knockdown. e The colonization of TUNEL (+) HNSCC cells under radiation dose of 4 Gy (left panel). The apoptosis rate was evaluated in miR-27a-3p mimics/inhibitor HNSCC cell lines (right panel). f Colony formation assay of miR-27a-3p mimics/inhibitor HNSCC cells (left panel). The number of colonies was counted and compared among different groups (right panel). Data were presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001