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. 2021 Aug 12;14:125. doi: 10.1186/s13041-021-00835-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Distinct biological processes and cellular components are enriched for genes upregulated after acute sleep deprivation. a Using Network Analyst software and the PANTHER: Biological Processes (BP) classification to perform overrepresentation analysis (ORA), pathways enriched for upregulated genes were identified. RNA splicing and Apoptotic Process were the most significantly enriched networks (Adjusted P-value = 0.025). These top networks have been expanded to show the genes that are involved and upregulated after sleep deprivation. b Using Network Analyst software and the PANTHER: Cellular Components (CC) classification to perform ORA we identified cellular components enriched for genes upregulated after sleep deprivation. The nucleus is the most significantly enriched (Adjusted P-value = 1.74 × 10^–9). The size of each node represents the number of hits from the inputted gene list