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. 2021 Aug 12;14:125. doi: 10.1186/s13041-021-00835-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Distinct biological processes and cellular components are enriched for downregulated genes after acute sleep deprivation. a Pathway analysis using the PANTHER:BP classification to perform ORA, pathways enriched for downregulated genes were identified. Cell adhesion is the most significantly enriched network (Adjusted P-value = 2.91 × 10^–3). The cell adhesion network has been expanded to show the genes that are involved and downregulated after sleep deprivation. b Using Network Analyst software and the PANTHER:CC classification to perform ORA we identified enriched cellular components for genes downregulated after sleep deprivation. The dendrite and postsynaptic membrane are the most significantly enriched cellular components (Adjusted P-value = 4.28 × 10^–7). The size of each node represents the number of hits from the inputted gene list