Table 4. Summary of RAS to any DAA in genotype 1a by time point.
Baseline | Post-failure | |
---|---|---|
Resistance to NS5a inhibitors | N=13 | N=18 |
24: K24R | 1 (8%) | 2 (11%) |
28: M28T | - | 5 (28%) |
M28V | 6 (46%) | 5 (28%) |
30: Q30H | 1 (8%) | - |
Q30L | - | 1 (6%) |
Q30R | - | 6 (33%) |
31: L31M | - | 2 (11%) |
58: H58D | - | 2 (11%) |
93: Y93F | 1 (8%) | - |
Y93H | - | 1 (6%) |
Y93N | 1 (8%) | 1 (6%) |
Resistance to NS5b inhibitors | N=7 | N=3 |
448: Y448H | 2 (29%) | - |
556: S556G | 5 (71%) | 3 (100%) |
Resistance to protease inhibitors | N=30 | N=14 |
36: V36M | 1 (3%) | 1 (7%) |
55: V55A | 3 (10%) | 2 (14%) |
V55I | 3 (10%) | 1 (7%) |
80: Q80K | 21 (70%) | 9 (64%) |
Q80L | 1 (3%) | - |
155: R155K | - | 1 (7%) |
168: D168A | - | 1 (7%) |