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Possible mechanisms affecting insulin secretion in CF patients. 1- CFTR mutations eventually lead to ductal obstruction, which causes an increase in proinflammatory cytokines. 2- The accrued immune infiltration in the pancreas of CF patients. 3- Changes in pancreatic tissue structure, such as amyloid deposition, exocrine tissue destruction and β-cell loss. These three pathways impact insulin production by β-cells.
