Table 1.

EVIDEM Core Model

Domains	Criteria
Need for Intervention	Disease severity
	Size of affected population
	Unmet needs
Comparative Outcomes of Intervention	Comparative effectiveness
	Comparative safety/tolerability
	Comparative patient-perceived health / PRO
Type of Benefit of Intervention	Type of preventive benefit
	Type of therapeutic benefit
Economic Consequences of Intervention	Comparative cost consequences – cost of intervention
	Comparative cost consequences – other medical costs
	Comparative cost consequences – non-medical costs
Knowledge about Intervention	Quality of evidence
	Expert consensus/clinical practice guidelines