Table I.
Clinical characteristics for all SJS/TEN patients
| Clinical characteristics | All (n = 123) | Early admission (n = 93) | Late admission (n = 30) | P value |
|---|---|---|---|---|
| Male | 47 (38%) | 35 (38%) | 12 (41%) | .72 |
| Age (years) | 56 (19) | 53 (19) | 67 (20) | .11 |
| Ethnicity | .30 | |||
| Chinese | 81 (66%) | 58 (63%) | 23 (77%) | |
| Malay | 29 (24%) | 25 (27%) | 4 (13%) | |
| Other | 13 (11%) | 10 (11%) | 3 (10%) | |
| Disease | .066 | |||
| SJS | 45 (37%) | 39 (42%) | 6 (20%) | |
| SJS/TEN | 41 (33%) | 30 (32%) | 11 (37%) | |
| TEN | 37 (30%) | 24 (26%) | 13 (43%) | |
| Maximum % BSA involved | 23 (22) | 20 (19) | 33 (27) | .016 |
| SCORTEN | 2.1 (1.2) | 2.0 (1.2) | 2.6 (1.2) | .013 |
| ABCD-10 | 2.0 (1.4) | 1.9 (1.5) | 2.2 (1.2) | .14 |
| Transfer∗ | 57 (46%) | 36 (39%) | 21 (70%) | .003 |
| Inciting Drug | .47 | |||
| Penicillin/cephalosporin antibiotic | 7 (6%) | 5 (5%) | 2 (7%) | |
| Other antibiotic | 8 (7%) | 5 (5%) | 3 (10%) | |
| Sulfonamides | 10 (8%) | 6 (7%) | 4 (13%) | |
| Allopurinol | 19 (15%) | 15 (16%) | 4 (13%) | |
| Anticonvulsants | 27 (22%) | 24 (26%) | 3 (10%) | |
| NSAID | 5 (4%) | 5 (5%) | 0 (0%) | |
| Trimethoprim-sulfamethoxazole | 2 (2%) | 1 (1%) | 1 (3%) | |
| Other drug | 27 (22%) | 18 (19%) | 9 (30%) | |
| Unknown drug | 1 (0.8%) | 1 (1%) | 0 (0%) | |
| SJS/TEN not caused by drug | 17 (14%) | 13 (14%) | 4 (13%) | |
| Comorbidities | ||||
| Malignancy | 18 (145%) | 13 (14%) | 5 (17%) | .72 |
| Liver disease | 4 (3%) | 3 (3%) | 1 (3%) | .98 |
| Renal disease | 17 (14%) | 13 (14%) | 4 (13%) | .93 |
| AIDS | 4 (3%) | 3 (3%) | 1 (3%) | .98 |
| Cardiac disease | 25 (20%) | 14 (15%) | 11 (37%) | .011 |
| Diabetes mellitus | 19 (15%) | 15 (16%) | 4 (13%) | .71 |
| Autoimmune/connective tissue disease | 11 (9%) | 8 (9%) | 3 (10%) | .82 |
| Charlson Comorbidity Index | 2.70 (2.69) | 2.57 (2.72) | 3.10 (2.63) | .28 |
Data are presented as count (%) or mean (SD). Bold values are statistically significant.
NSAID, Non-steroidal anti-inflammatory drug.
∗
Indicates the number of patients transferred to Singapore General Hospital.