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. 2021 May 21;73(7):968–977. doi: 10.1002/iub.2503

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© 2021 The Authors. IUBMB Life published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Lovastatin‐induced cell death increases after p21 inhibition with UC2288. BCBL1 cells were pre‐treated with UC2288 (UC) and then cultured with Lovastatin (L) (30 μM) for 48 h and (a) cellular viability was evaluated by Trypan blue exclusion. % of cell survival is shown. * < 0.05; (b) PARP1 cleavage (PARPcl) was assessed by western blotting; (c) DNA content was measured with Propidium Iodide staining and analyzed by flow cytometry. The percentage of sub‐G1 events is reported. FACS plots are representative of at least three independent experiments. The Student t test was used for statistical significance of the differences between treatment groups. Statistical analysis was performed using analysis of variance at 5% (p < .05). The Student t test was used for statistical significance of the differences between treatment groups. Statistical analysis was performed using analysis of variance at 5% (p < .0)