TABLE 2.
Genes involved in acetic acid tolerance
| Gene | Function | Acetic acid tolerance | Methodology | Strain background | Reference |
|---|---|---|---|---|---|
| FPS1 | Aquaglyceroporin | + | Deletion | BY4741 | Mollapour and Piper (2007) |
| ADY2 | Acetate transporter | + | Deletion | BY4741 | Zhang et al. (2017) |
| PDR18 | Transporter of ABC family | − | Deletion | BY4741 | Godinho et al. (2018) |
| PMA1 | Plasma Membrane H+‐ATPase | + | Overexpression | BY4741 | Lee et al. (2017) |
| VMA3 | Vacuolar H+‐ATPase | − | Deletion | BY4741 | Konarzewska et al. (2017) |
| HAA1 | Transcriptional activator for weak acid stress | + |
Deletion/Transcriptomics Overexpression |
BY4741 S288C |
Mira, Becker, and Sá‐Correia (2010) and Tanaka et al. (2012) |
| RTG2 | Sensor of mitochondrial dysfunction | − | Deletion | W303 | Guaragnella et al. (2013) |
| HOG1 | Mitogen‐activated protein kinase | − | Deletion | W303 | Guaragnella et al. (2019) |
| RCK1 | Protein kinase | + | Overexpression | D452‐2 | Oh et al. (2019) |
| WHI2 | Protein phosphatase activator | +/− |
Overexpression Deletion |
D452‐2 | Chen et al. (2016) |
| SET5 | Methyltransferase | + | Overexpression | BY4741 | Zhang et al. (2015) |
| PPR1 | Zinc finger transcription factor | + | Overexpression | BY4741 | Zhang et al. (2015) |
| CTT1 | Cytosolic catalase | + | Overexpression | W303 | Guaragnella et al. (2008) |
| JJJ1 | ATPase activator | + | Deletion | BY4741 | Wu et al. (2016) |
| RTT109 | Histone acetyltransferase | + | Deletion | BY4741 | Cheng et al. (2016) |
| ACS1 | AcetylCoA‐synthetase 1 | + | Overexpression | XM19/XM20 | Ding et al. (2015) |
| ACS2 | AcetylCoA‐synthetase 2 | + | Overexpression | S288C | Qin et al. (2020) |