Table 5.
Evaluation of the broad‐spectrum antiviral effect of 10 against a representative panel of clinical EV71 isolates in RD cells.
|
EV71 genogroup |
Virus strain |
EC50 [μM][a] |
|
|---|---|---|---|
|
10 |
AL‐385 |
||
|
A |
BrCr |
334±41 |
285±70 |
|
B2 |
11316 |
517±120 |
0.4±0.0 |
|
B5 |
TW/70902/08 |
87±10 |
0.2±0.1 |
|
C2 |
H08300 461#812 |
95±7 |
1.1±0.3 |
|
C4 |
TW/1956/05 |
68±4 |
0.2±0.2 |
[a] All values are in nanomolar (nM) concentrations and were obtained in multiple (>2) independent (>1) experiments. Following microscopic quality control, at least at one concentration of compound, no virus‐induced cell death was observed, and the compound did not cause any morphological changes in the host cell monolayers.